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Practical Implication: This research validates that topical GHK-Cu formulations achieve meaningful tissue concentrations, supporting the rationale for both cosmetic and research applications

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Histologically, MPNSTs are characterized by dense cellularity, mitotic figures, nuclear atypia, geographic necrosis, and fascicular growth patterns

Loss of lean tissue, comprising skeletal muscle, bone, organs, and body water, is therefore an important consideration in patients undergoing weight reduction with GLP-1RAs

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J Diabetes Res 2019(9426014)