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Bibcode:1978Natur.273..120S

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M1 macrophages, typically activated by IFN-, are characterized by the production of IL-1, TNF-, IL-6, and iNOS, and are closely associated with synovial inflammation and tissue destruction (106)

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The subcutaneous vs intramuscular peptide injection route decision for BPC-157 is therefore often based on the specific tissue being studied rather than systemic bioavailability considerations