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The effects of Exendin-4 were abolished in the presence of Exendin (939), but remained intact when insulin secretion was abrogated by diazoxide (Fig

Baseline Demographics by Race Source: Adapted from FDA Review Figure 3 summarizes the percentage of patients by age enrolled in the clinical trial used to evaluate efficacy and safety

Interestingly, proflavine, potentially a lead compound, did not initially qualify as a lead compound based solely on signal activation from a promoter study