Heise T, Mari A, DeVries JH et al (2022) Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial
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Outlandish claims of effortless weight loss and reversal of diabetes with no side effects should be met with extreme skepticism, especially when not evaluated and approved by reputable regulatory agencies like the FDA, or backed by peer-reviewed clinical research
This is relevant for the short-acting GLP-1 agonists, whereas tachyphylaxis rapidly develops for the long-acting agonists [8]
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