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Step 3: Treatment

Conversely, higher concentrations of NT in the NAc increase dopamine release, which may be mediated by NTS1 on presynaptic dopaminergic terminals, and would be predicted to enhance the effects of psychostimulants (Figure 2A) (Reyneke et al., 1990

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The researchers administered 2.4 mg subcutaneous semaglutide (Wegovy, Novo Nordisk) once weekly to patients with obesity and moderate knee OA, who had at least moderate pain, and compared their outcomes with a placebo group over 68 weeks