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These effects are usually mild to moderate, occur most frequently when starting treatment or increasing doses, and often improve over time

Figure 3 The specific involvement of TGR5 in the cAMP response to OA was further examined using TGR5 specific siRNA

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doi:10.3389/fendo.2025.1621892 Nagae K, Uchi H, Morino-Koga S, Tanaka Y, Oda M, Furue M

Furthermore, since the GLP-1 receptors are trafficked and inserted into the axon terminal membranes, that may make it difficult to visualize binding, because one is looking at diffuse scattered axon terminals rather than concentrated neuronal cell body labeling