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Tirzepatide suppresses appetite but does not prevent calorie consumption if you override the appetite signal

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The gut/ brain axis is the reason we get butterflies in our stomach when we see our crush, lose our appetite when we are sad, or go to the bathroom when we are nervous

Savjani, K.T., Gajjar, A.K

Biochem J 430:439451 Lewerenz J, Ates G, Methner A, Conrad M, Maher P (2018) Oxytosis/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system