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doi: 10.1161/01.cir.0000015507.29953.38 19 ChenK.FebbraioM.LiW.SilversteinR
2021 May 28;10(6):1343
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Archived from the original on July 25, 2009
Metabolic approaches: GLP-1 Incretins (semaglutide): appetite suppression | GLP-1/GIP incretins (tirzepatide): dual hormonal agonism | 5-Amino-1MQ: NNMT enzyme inhibition a non-hormonal mechanism, directly targeting lipid and NAD+ metabolism
Safety profile from completed Phase 2 trials shows retatrutide is comparable to FDA-approved alternatives
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