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Predictions of the in vivo clearance of drugs from rate of loss using human liver microsomes for phase I and phase II biotransformations

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In the human skeletal muscle (pH 7.1), which lacks carnosinase-1, the degradation of carnosine by carnosinase-2 is very limited, because its optimal pH 9.5 is much greater than the intracellular pH and its V max is 30 times lower than that of carnosinase activity in the human kidneys (Lenney et al

POLG mutation testing should be performed in accordance with current clinical practice for the diagnostic evaluation of such disorders

Further evidence suggests the need to rationalise the use of vitamin be 12 in general practice