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Methylcobalamin is best, unless you suffer from Lebers hereditary optic neuropathy (1 in 30,000 to 50,000 people), where hydroxy B12 is safer
From a mechanistic standpoint, their actions are not mutually exclusive
C ssav = AUC 0t /, is the interval of administration;C ssmin =(C -48h + C -24h + C 0h )/3
This also highlights the role of neurons in contributing to BBB maintenance and breakdown [115]
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