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In contrast, at higher concentrations, MB may start to divert electrons away from the normal chain and inhibit the respiratory enzymes, which could decrease ATP generation and increase oxidative stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Li KP, Yang XS, Wu T

During the break, continue topical application only

The fate of melanocyte: mechanisms of cell death in vitiligo

Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

Effective beginner concentrations are 1 to 2%