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All viral glycoproteins share the characteristic of their assembly into oligomers that necessitates the formation of a disulfide bond and this is inhibited by the reducing action of GSH
PubMed Desilets AR, et al
If the rubber stopper shows signs of coring (pieces breaking off into the solution), if the crimp cap is loose, or if there is any indication that the vial has been tampered with or improperly sealed, the sterility cannot be guaranteed
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