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10.1186/s13643-015-0133-0 28 ChangM

Well-designed animal experiments and clinical trials are needed to evaluate the efficiency of these compounds

Common side effects and management The most frequently reported side effects of semaglutide include nausea (especially in the first weeks and after dose increases), constipation, diarrhea, abdominal pain, and fatigue

Combination with Metformin or Metformin with Sulfonylurea In a 26-week, double-blind trial (Trial 3, NCT02607865), 1864 adult patients with type 2 mellitus diabetes on metformin alone or metformin with sulfonylurea were randomized to RYBELSUS 3 mg, RYBELSUS 7 mg, RYBELSUS 14 mg or sitagliptin 100 mg once daily

Having established cardiovascular disease, thus benefiting from a lowered risk of major cardiovascular events