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The net effect likely depends on individual patient factors and how well the pro-thrombotic risks are managed

In mice plasma TMAO has been shown to be higher in female and TMA lower compared to males as Flavin-Containing Monooxygenase 3 (the main TMAO producing enzyme) expression is drastically downregulated by testosterone (and mildly upregulated by estrogen

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If it is significantly past BUD, was subject to temperature excursions, or shows any visual changes, discard it

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