glp 1 drugs origin

glp 1 drugs origin The Landscape Of GLP-1 Receptor Agonists In Diabetes And Obesity Treatment Structure-Based Discovery of Orthosteric Non-Peptide

Name: glp 1 drugs origin The Landscape Of GLP-1 Receptor Agonists In Diabetes And Obesity Treatment Structure-Based Discovery of Orthosteric Non-Peptide
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Sano S, Tao S, Endo Y, Inaba T, Hossain MA, MIYAKE C, Matsuo M, Aoki H, Asada K, Saito K

Chemosphere 56 , 659666 (2004)

The molecule consists of a modified GLP-1 analog, containing three key amino acid substitutions: Ala8Gly, Gly22Glu, and Arg36Gly, covalently fused to the Fc (constant) region of human immunoglobulin G subclass 4 (IgG4) (Fig