Data-dependent MS2 fragmentation for compound identification and annotation was performed via the AquireX workflow (Thermo Scientific), which comprised three deep scans with MS1 resolution at 60,000 and MS2 resolution at 15,000
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In contrast, the GSH-treated samples appeared relatively normal, and their mitochondria were characterized by abundant, large, and clear cristae (Fig
Furthermore, several novel GLS inhibitors have exhibited superior therapeutic efficacy in clinical settings and preliminary studies, such as IN-3, have been shown to possess antiproliferative effects on PCa