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reported that CTGF increased the activity of focal adhesion kinase (FAK), mitogen-activated protein kinase kinase (MEK), and ERK proteins (143), which is consistent with the findings of Tan and colleagues that CTGF promotes chondrosarcoma cell migration by increasing the expression of MMP-13 via the v3 integrin, FAK, ERK, and NF-B signal pathways (144)
NEK2 affects the ferroptosis sensitivity of gastric cancer cells by regulating the expression of HMOX1 through Keap1/Nrf2
Allerdings hat der Wirkstoff keine Zulassung als Arzneimittel erhalten, da es bei der Anwendung zu sehr starken Nebenwirkungen kommt
10.1097/shk.0000000000000390 178 WangJ.ZhuH.YangZ.LiuZ
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