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SAP is often associated with distant organ injury, including the heart, lungs, brain, and kidneys [2, 3]

It exerts its effects through multiple mechanisms, including: VEGF receptor modulation (vascular endothelial growth factor)promoting angiogenesis and blood vessel formation Growth hormone receptor interaction facilitating tissue repair and regeneration Nitric oxide pathway activation improving blood flow and reducing oxidative stress FAK-paxillin pathway signaling crucial for cell migration and wound healing Modulation of inflammatory cytokines reducing excess inflammation while preserving healing responses These are cascading processes

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Patients with germline alterations indicative of increased risk of RN may be poor candidates for SRS

Medical professionals are trained to handle such situations and can provide the necessary assistance or alternatives