Glucagon-like peptide-1 receptor agonists (GLP-1RAs), along with glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) dual or triple receptor agonists that modulate multiple metabolic pathways, have attracted significant scientific interest due to their multifaceted roles in metabolic regulation
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The phase of a trial reveals what stage the drug is in to get approval for a specific condition
A 2025 network meta-analysis ranked nausea risk as follows: orforglipron (highest, relative risk 4.77), liraglutide (3.09), semaglutide (2.94), tirzepatide (2.89), exenatide (2.66), and cagrilintide (2.29)
