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Complete physical and neurological examination were performed laying stress on anthropometric measurements [weight (kg), height or length (cm) and body mass index (kg/m 2 )] which were measured and plotted on the WHO Z score for children up to 5 years of age 15 , while CDC 2000 growth charts have been used for those above 5 years of age

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Biodistribution study The biodistribution of NP4 in orthotopic osteosarcoma mouse model was investigated using in vivo imaging system (IVIS)