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Mechanistic experiments using the PI3K inhibitor wortmannin demonstrated that PI3K/AKT signaling is required for the anti-inflammatory and anti-apoptotic effects, identifying the brain AngIV/PI3K/AKT axis as the proximate mechanism in this model

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You are taking a lot of different things, some of which may be conflicting slightly or using up/locking up vitamins and minerals and producing symptoms as a result