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The evidence: A 2025 RCT published in Frontiers in Nutrition randomized 80 patients to 3,000 mg/day low-molecular-weight collagen peptides or placebo for 180 days

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Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates

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However, chronic high-volume fasted cardio can elevate baseline cortisol and disrupt sleep quality, which indirectly impairs the nocturnal GH pulse that the peptides are designed to amplify

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