Theoretical Benefits: Weight Loss and Inflammation GLP-1 agonists are primarily approved for weight loss and diabetes management
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A dose-dependent increase in heart rate was observed with retatrutide
[1] Neither Semaglutide nor Tirzepatide incorporates this third mechanism, making glucagon receptor agonism the feature most frequently cited as differentiating Retatrutide from approved comparators
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In particular, retatrutide, a triple agonist targeting GLP-1 receptors, GIP, and glucagon receptors, has demonstrated substantial metabolic benefits, raising interest in its potential for treating substance use disorders as well (Jastreboff et al