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1,2 Any decision about weight-loss injections for someone under 18 should involve a specialist obesity service and the young persons parents or guardians

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Analysis: The peptide problem: Hype is outrunning the evidence With flimsy or no evidence that using unauthorized peptide drugs is effective in humans, buying the online and self-injecting is high-risk, uncontrolled human self-experimentation, writes Stuart Phillips

streptozotocin-induced T1DM) and T2DM (db/db mice, Zucker rats) (Tejada et al., 2008

Participants using Zepbound (tirzepatide) achieved an average weight loss of 20.2% compared to 13.7% with Wegovy (semaglutide), translating to 50.3 pounds versus 33.1 pounds of weight reduction respectively ^2

As a standalone medication, current data suggest cagrilintide produces less weight loss than both Wegovy and Zepbound