tirzepatide news september 27 2025 confers wide range of benefits in type 1 diabetes GLP-1 Pipeline Update: May 2025

In the PIVENS randomized controlled trial, patients with biopsy-proven NASH without diabetes mellitus received vitamin E (800 IU/day) and pioglitazone (30 mg/day) for 96 weeks and were compared with patients who received placebo

For instance, berberine, a natural compound, downregulates the expression of SLC1A5 in Hep3B and BEL-7404 cells, inhibiting Gln uptake and consequently suppressing expansion of liver cancer cells and tumor progression in vivo (77)

These are significant outcomes from serious peer-reviewed clinical research

Clinical trials show constipation occurs in 1525% of people on semaglutide, depending on dose and individual genetics

An additional 14% expressed interest in trying them, while 74% said they do not intend to use the drugs

What to tell your doctor If you arrived at this article because you were unsure whether your Tresiba prescription is a GLP-1 medication, here is what to discuss with your healthcare provider