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Topical application of PEPITEM not only reduced local inflammation but also had systemic effects, such as reducing disease-related splenomegaly and limiting the expansion of CD4+, CD8+, Th1, and Th17 T-cell populations in the spleen

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The SURMOUNT-4 trial demonstrated that following 36 weeks of tirzepatide (producing 21.1% weight loss), continuing medication yielded an additional 5.5% reduction, while switching to placebo resulted in 14% weight regain

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PMID 23106397 "Activation of the insulin-like growth factor-1 receptor alters p27 regulation by the epidermal growth factor receptor in oral squamous carcinoma cells." ( Molecular and Cellular Endocrinology , 2013)