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REDEFINE 2, focused on type 2 diabetes, showed a mean 13.714.25% body weight reduction over 68 weeks with CagriSema compared to roughly 3% with placebo

FOXO4-DRI is a D-retro-inverso peptide, meaning its amino acid sequence is reversed and uses mirror-image D-amino acids, making it resistant to enzymatic degradation while maintaining binding activity

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(PubMed) Franke B, Vermeulen SH, Steegers-Theunissen RP, et al