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LaccID was more stable than our starting template LacAnc100, with a T 50 (temperature at which the enzyme loses 50% of activity after 10 min of incubation) of 57.8 0.5 C compared to 54.8 0.2 C for LacAnc100 (Fig
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These conjugates leverage FOLR1-mediated endocytosis for selective entry into cancer cells, enabling the specific degradation of BRD, MEK1/2, and ALK fusion proteins without affecting non-malignant cells
The emission was recorded using the top optic detector and the orbital averaging mode (diameter: 3 mm and 30-35 light flashes)
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