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Risk-benefit implications With increasing prevalence of GLP-1 agonists in our perioperative population and emerging reports of retained gastric content despite recommended fasting guidelines, a review on the perioperative handling of GLP-1 agonists and assessment of these patients are warranted to balance their cardiometabolic benefits and unquantified risk of catastrophic pulmonary aspiration

doi:10.12703/r/10-7

In general, the efficacy of a drug to fight metastatic cells might depend on the preferred source of energy in concert with the proliferation efficacy

& Anselmo, J

Resmetirom (MGL-3196), for instance, has shown strong results in Phase II and Phase III trials

Since cellular performance adaptations arise from gene expression changes, the team screened for regulatory proteins that can flip on advantageous gene programs during prolonged GLP-1 use