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Clinical evidences have demonstrated that glibenclamide, a prototypical sulfonylurea, is associated with a significantly increased cancer risk occurrence [107]

The uremic toxin homocysteine exacerbates the brain inflammation induced by renal ischemia-reperfusion in mice

Mechanistically, SRD5A1 downregulation simultaneously regulated both the Bcl-2 family protein-mediated apoptosis and the autophagic process via PI3K/Akt/mTOR signaling pathway in MM cells

Stem Cell Res Ther (2016) 7:24

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Novo Nordisk is currently testing a long-acting amylin analogue, AM833, in overweight and obese individuals in phase I and II clinical trials (138, 139)