Gut microbial signatures for glycemic responses of GLP-1 receptor agonists in type 2 diabetic patients: a pilot study
A., Dvorkin, E., Homel, P., Malamud, S., Culliney, B., Lapin, J., & Esteban-Cruciani, N
This study used: National register infrastructure across multiple countries Active comparators (DPP-4 inhibitors) Quantified upper confidence bounds to show maximum plausible effect size International Multisite Cohort (Thyroid Journal) Analysis of six population-based databases found no evidence of increased thyroid cancer risk with GLP-1 RA use over 1.8-3.0 years follow-up
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This approach helps preserve comparability across runs and allows later replications to be performed under comparable assumptions