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Currently, the effects of 2.4 mg semaglutide once weekly are being explored in 1200 participants with biopsy-confirmed NASH in a Phase III clinical trial with a combined primary endpoint of resolution of NASH without worsening fibrosis, improvement in liver fibrosis without worsening of steatohepatitis, and time to first liver-related clinical event (NCT04822181) (see Table 2)

This is one area where the long-term benefits of semaglutide may actually outweigh the short-term indirect risks from side effects

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NNMT is highly expressed in fat tissue, which has made its inhibition a focus of metabolic research