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Participants will be randomized in a 1:1 ratio to receive either 400 mg SAMe or matched placebo orally once per day for 180 days

Song, X.Z

Amin, A

Sato et al., 2019), thus, providing substrates for AF

Key evidence comes from STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)