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Why electrolytes matter on a GLP-1 GLP-1 medications work largely by reducing appetite and slowing how fast your stomach empties, which is exactly why they help with weight (the mechanism is laid out well by Drucker and confirmed in the STEP-1 trial)

Dr Jose Villamarin

Hamamoto et al., 2020

The NHS pathway under NICE TA1026 currently restricts tirzepatide to a BMI of 40 or above with four of five qualifying conditions, with the threshold widening over the next 12 years

Vitamin C in extremely high doses (more than 1000 mg taken with a b12 supplement) may reduce b12 absorption when taken together