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Loganin alleviated cognitive impairment in 3Tg-AD mice through promoting mitophagy mediated by optineurin

The American Diabetes Association Standards of Care acknowledge gastrointestinal tolerability as a key consideration when initiating GLP-1 receptor agonist therapy, recommending gradual dose titration to minimize these effects

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Additionally, GIPRs unique activation in the brain and white adipose tissue (WAT) might complement GLP-1R signaling, potentially improving therapeutic outcomes Figure 2