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Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks

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The safety margin is over 300 times the therapeutic dose, making GHK-Cu one of the safest peptides available for research use

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[2] A 2023 study in the Journal of Cosmetic Dermatology found GHK-Cu and hyaluronic acid combined to synergistically upregulate collagen types I, IV, and VII

For further clarification and to show a direct beneficial effect, medication was given once as a bath to the segment of left colic artery and vein obstructed by two ligations