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However, the addition of NAD + and CoA did not restore functional lipoylation within 30 min, suggesting that while the intrinsic capacity of the OGDHc may resolve lipoyl adducts over time, ABHD11 restores functional lipoylation more rapidly

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This latter observation is strong evidence that adipocytes play a major regulatory role in the HBP-mediated whole-body insulin resistance

M., Vander Hoorn, S