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But medical literature evidence suggests these same pathways may interfere with key skin functions by: Slowing fibroblast activity, reducing the production of structural proteins like collagen and elastin Decreasing cell turnover, leading to dullness and slower skin renewal Compromising the skin barrier, increasing water loss and sensitivity to environmental damage The result

Metabolomics analysis of human plasma reveals decreased production of trimethylamine N-oxide retards the progression of chronic kidney disease

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These improvements correlate with reduced cardiovascular risk

Freckles mostly affect people with lighter skin tone because for the people with darker skin tones, melanin deposition is a natural skin defence which ends up resulting in pigmentation or dark spots