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Among the tissues and organs crucial in regulating glucose and lipid metabolism, pancreas, brain, and adipocytes express GIP receptors (GIPRs), while pancreas, brain, and gastrointestinal tract are rich in GLP-1 receptors (GLP-1Rs) (40)
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Clinical studies A total of 22 completed clinical studies were identified (Table 1 and Extended Data Tables 1 and 2), with another 8 clinical trials still ongoing (Supplementary Section 3)
Patients taking insulin or sulfonylureas alongside retatrutide face an increased risk of hypoglycaemia and require close monitoring
Referral is recommended when the diagnosis is unclear, lesions are atypical, or systemic involvement is suspected
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