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Wink L, Adams R, Wang Z, Klaunig JE, Plawecki MH, Posey DJ, McDougle CJ, Erickson CA (2016) A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder

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Under a treatment duration of 24.3 18.9 months (range 6 to 51), metabolic parameters also improved [homeostatic model assessment of insulin resistance 3.2 3.5 (range 9.1 to 0.8)

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In addition to creating 5-carbon sugars used in nucleotide synthesis, the PPP generates NADPH, which is required to maintain homeostatic levels of the antioxidant glutathione (GSH)