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De Simone G, Mazza B, Vellucci L, Barone A, Ciccarelli M, de Bartolomeis A: Schizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment

HIFs are heterodimers consisting of an oxygen-dependent -subunit (HIF-) and an oxygen-independent -subunit (HIF-)

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Animal studies show 15-25% increases in muscle mass over 4-6 weeks at doses of 50-150 mcg/kg/day

Interference with the pentose phosphate pathway by directly targeting G6PD using the antiinflammatory compounds dimethyl fumarate or parthenolide leads to complete depletion of GSH and concentration-dependent eryptosis [113]