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By modifying the OXM peptide sequence with an amino acid-peptide substitution at position 2 to prevent DPP-4 action, in addition to a cholesterol-peptide conjugate, Pocai and colleagues were the first group to show that synthetic dual-agonists were an effective treatment strategy in an animal model

European Heart Journal, 33 (7), 829

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The results of those studies show the following

Diabetes, vascular disease and other underlying conditions can themselves increase the risk of impaired blood flow to the optic nerve

Who were among the first to step out and say, "Yep, I tried it"