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However, within the TMD, the exendin-4 bound cavity is more open, predominantly due to a more outward location of TM1, however, TM2, TM4-ECL2-TM5 and TM7 are also located further from the centre of the bundle (Fig

Ultimately, 1,25(OH)D, bound to VDBP, enters target cells and binds to its nuclear receptor, the Vitamin D receptor (VDR)