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Common side effects The most frequently reported side effects during the first four to eight weeks of semaglutide treatment include nausea (affecting 40-45% of users initially), constipation (approximately 24%), diarrhea (around 30%), abdominal bloating (roughly 20%), reduced appetite (this is actually the intended effect), fatigue (reported by 15-20% of users), and headaches (approximately 14%)

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These responses are tightly integrated with hormonal signaling networks especially auxins, ethylene, and cytokinins which modulate root architecture and rootshoot communication

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Prolonged Fullness: Feeling uncomfortably full long after eating

Reduced appetite does not always lead to immediate weight loss