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Nausea, vomiting, and diarrhea are common, and depending on the person there are real risks of acute kidney injury, gallstones, and pancreatitis, plus muscle and bone loss in older adults

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Processing times range from 3 to 10 business days, and denial rates for initial requests vary from 15 to 45 percent depending on state formularies and clinical documentation quality

This characteristic makes protocol adherence particularly important for researchers seeking reliable data