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If full meals feel overwhelming, try eating every 34 hours instead of waiting until you're hungry

Nature (2025)

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Lancet (2019) 394(10193):1318

This is significantly higher than standard recommendations and often requires protein supplementation to achieve

Notably, tirzepatide is characterised in the literature as an imbalanced or biased dual agonist: its affinity for the GIP receptor is comparable to native GIP, while its affinity for the GLP-1 receptor is roughly 18- to 20-fold weaker than native GLP-1