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Cain KC, Headstrom P, Jarrett ME, Motzer SA, Park H, Burr RL, et al

doi: 10.1016/j.neubiorev.2020.10.004

References: Monnier, M., Duds, B., & Prochiantz, A

Cycle Guidelines Common Cagrilintide + Tirzepatide Cycle Approaches Approach Full staggered titration Duration 24-week ramp + open-ended maintenance Off Period No standardized off period Best For Primary weight-loss strategy with full pathway coverage Approach Tirz-first, cag add-on Duration Stabilize tirzepatide at 10-15 mg, then add cag for 12+ weeks Off Period Cag can be cycled on its own Best For Users already on tirzepatide who want more satiety Approach Sub-maximal combination Duration Lower doses of each (e.g

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Kidneys: NAD+ therapy may help to protect the kidneys from damage