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In contrast, brain-first PD is characterized by initial central -syn pathology, for example, in limbic structures or the olfactory bulb, with subsequent spread to peripheral sites

Molecules 24(11):2191 Reinke D, Kritas S, Polychronopoulos P, Skaltsounis AL, Aligiannis N, Tran CD (2015) Herbal substance, acteoside, alleviates intestinal mucositis in mice

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Leyden J, Dunleavy K

Another study by Sudakov et al