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The compound simultaneously activates three receptors that have historically been engaged separately or in pairs: GLP-1R (Glucagon-Like Peptide-1 Receptor)

In a nested case-noncase study by Battini et al, 24 all signal detection methodologies and disproportionality statistics investigating the GLP-1 analogs, in particular, liraglutide and glicazide, agreed on its statistically significant potential antidepressant effect

mtROS are generated by inefficient electron transfer through the ETC 104 , and defects in the ETC have been shown to increase mtROS even further 105

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Topiramate increases kidney stone risk, and adequate fluid intake is the simplest protective measure