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In pancreatic -cells, the primary role of GLP-1R is to promote -cell proliferation, stimulate insulin synthesis and secretion, and inhibit glucagon synthesis and release

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Specifically, the cut-off distance is 4.0 for salt bridge analysis [50], while the hydrogen bond analysis employed two criteria: (a) a cutoff value of the angle formed by acceptor (A), donor (D) and hydrogen (H) ( ADH ) of 30